Yes, they are different!
1. Have the force of law.
2. Regulations are required when legislation becomes law.
3. must go through a process before being finalized and legally applicable.
1. Clarification of a particular existing regulation by an agency.
2. Does not have the force of law.
3. Policy based.
When the Circuit Courts are divided, such as they seem to be in the ADA online compliance, guidance is welcomed.
DM to help your website be legally compliant.